High Prevalence of Lingering Symptoms Seen Among Previous COVID Patients

High Prevalence of Lingering Symptoms Seen Among Previous COVID Patients
High Prevalence of Lingering Symptoms Seen Among Previous COVID Patients

United States: In a recent cross-sectional investigation featured in JAMA Internal Medicine, involving 238,828 blood contributors, it was discovered that 43.3% of individuals with a precedent of SARS-CoV-2 contraction noted novel enduring symptoms, as opposed to 22.1% lacking such a history.

“The disparity in these ratios hints that roughly 21.2% of contributors with antecedent SARS-CoV-2 exposure plausibly encountered lingering symptoms ascribed to their infection,” elucidated the researchers.

This study marks one of the pioneering inquiries into the realm of prolonged COVID, contrasting cohorts with prior COVID exposure and persistent symptoms against a control group absent of SARS-CoV-2 infection. This comparative analysis, according to the authors, facilitates the delineation of baseline symptom prevalence from those ensuing post-COVID-19.

Validation of former infection via blood assays

The research encompassed adult donors to the American Red Cross, surveyed between February 22 and April 21, 2022. The questionnaire probed for recent lingering symptoms emerging post-March 2020 and their status regarding SARS-CoV-2 infection.

Inforgraphic sharing information related to COVID.

Fifty-eight percent of respondents were of the feminine gender, with an average age of 59 years. All participants underwent at least one serologic assay for anti nucleocapsid antibodies between June 15, 2020, and December 31, 2021. These antibodies manifest in the bloodstream solely following a bout of COVID-19, distinct from vaccination-induced antibodies.

“Serologic testing to substantiate former infection could be especially advantageous for the scrutiny of post–COVID-19 conditions, given that many SARS-CoV-2 infections go undetected, and numerous asymptomatic or mildly symptomatic individuals remain untested during the acute phase,” the authors stipulated.

Gender and chronic ailments correlated with prolonged COVID

The investigators delineated enduring symptoms as those persisting for four or more weeks post-COVID-19 infection. Inquiries categorized enduring symptoms by system: neurological, gastrointestinal, respiratory or cardiac, psychological, and miscellaneous.

Among the 83,015 individuals with a history of SARS-CoV-2 infection, 43.3% relayed novel enduring symptoms, juxtaposed with 22.1% of those sans such a history (adjusted odds ratio [AOR], 2.55; 95% confidence interval [CI], 2.51 to 2.61).

Female gender and antecedent chronic health conditions exhibited an association with prolonged COVID symptoms.

Among the people who had earlier SARS-CoV-2 infections, 23.6% of them agreed that they reported enduring neurological symptoms, 23.1% claimed other symptoms (for example, taste and olfaction), 15.8% declared some respiratory or cardiac symptoms, 11.9% agreed that they suffered psychological symptoms, while in 4.6

Cognitive impairment and fatigue are prevalent

The shortening of duration and the stronger correlation (AOR, 4.14; 95% CI, 4.03 to 4.25; and AOR, 3.21; 95% CI, 3.12 to 3.31, respectively) with prior COVID-19 infection for these symptoms in “miscellaneous”.

Visual Representation

The four most common 5-month cognitive impairments were confusion or difficulty with concentrating (12.7%) and fatigue (11.1%). Anxiety was the symptom or enduring symptom experienced by a larger number of individuals without a record of COVID-19 than other symptoms among people surveyed, which indicates that anxiety was the most common symptom known among those questioned.

“Mental health symptoms surfaced nearly as frequently in both cohorts, indicative of indirect repercussions,” concluded the authors.


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